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A medicine called methotrexate is used to treat very bad cases of psoriasis that can’t be controlled by other medicines. People who have rheumatoid arthritis that is very active and can’t be controlled by other medications also take methotrexate along with rest, physical therapy, and sometimes other medicines to treat it. In addition, methotrexate is used to treat some types of cancer, such as cancers that start in the tissues that form around a fertilized egg in the uterus. It is also used to treat cancers of the breast and lung, as well as some types of lymphoma and leukemia.